Immunoregulatory role of interleukin 10 in rheumatoid arthritis.
نویسندگان
چکیده
منابع مشابه
Immunoregulatory role of interleukin 10 in rheumatoid arthritis
The presence and the role of interleukin 10 (IL-10), a potent cytokine synthesis inhibitory factor and antiinflammatory cytokine, were investigated in rheumatoid arthritis (RA). The expression of both mRNA and protein for IL-10 could be demonstrated in RA and osteoarthritis (OA) joints. Human IL-10 mRNA could be demonstrated by polymerase chain reaction amplification of cDNA made by reverse tra...
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Interleukin (IL) 10 looms as a highly promising treatment for rheumatoid arthritis (RA) because of its capacity to inhibit cellular immunity and deactivate macrophages. In RA, activated CD4 T helper cells and macrophages are believed to be the primary driving force behind joint inflammation. Synovial macrophages play a critical part in stimulating synovial inflammation. They produce abundant qu...
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These include: References http://ard.bmjjournals.com/cgi/content/full/62/suppl_2/ii48#BIBL This article cites 19 articles, 14 of which can be accessed free at: Rapid responses http://ard.bmjjournals.com/cgi/eletter-submit/62/suppl_2/ii48 You can respond to this article at: service Email alerting top right corner of the article Receive free email alerts when new articles cite this article sign u...
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Background and aims: Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and its expression is increased in rheumatoid arthritis (RA). A number of novel cytokines have been found recently, which have been designated as the IL-10 family based on their genetic characteristics. These cytokines include IL-19, IL-20, IL-22, IL-24 and IL-26. Information concerning the expression and function of ...
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The progressive destruction of cartilage and bone in rheumatoid arthritis(RA) cause substantial effects in the synovial membrane and, this is dangerous for rheumatoid arthritis patients, macrophages play a potent stimulating role in synovial inflammation. Accordingly, we purposed in this review to study both treatment of AR by interleukin 10 (IL-10), and receptors with signalization pathway IL-...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1994
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.179.5.1517